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DIPHTHERIA TOXIN
Descriptors Found:
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DeCS
Descriptor
English
:
Diphtheria Toxin
Descriptor
Spanish
:
toxina diftérica
Descriptor
Portuguese
:
Toxina Diftérica
Synonyms
English
:
Corynebacterium Diphtheriae Toxin
Toxin, Corynebacterium Diphtheriae
Tree Number:
D08.811.913.400.725.115.220
D23.946.123.305
Definition
English
:
An ADP-ribosylating polypeptide produced by
CORYNEBACTERIUM DIPHTHERIAE
that causes the
signs and symptoms
of
DIPHTHERIA
. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE)
TRANSFERASES
which transfers ADP
RIBOSE
to
PEPTIDE ELONGATION FACTOR 2
thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Indexing Annotation
English
:
/antag permitted but consider also
DIPHTHERIA ANTITOXIN
Pharmacological Action:
Poisons
See Related
English
:
Diphtheria Toxoid
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
4224
Unique Identifier:
D004167
Occurrence in VHL
:
Similar:
DeCS